PMID: 463544Jul 1, 1979

Hemoglobin A1c (HbA1c) in children with long standing and newly diagnosed diabetes mellitus

Acta paediatrica Scandinavica
E HeinzeE Kleihauer

Abstract

In 35 children with long-standing diabetes mellitus, a significant correlation was found between the hemoglobin A1c (HbA1c)--and the 24-hour urinary glucose excretion. By contrast, 11 newly diagnosed diabetic children had grossly elevated HbA1c-concentrations, but no correlations could be established between the levels of HbA1c and the duration of symptoms, blood glucose, glycosuria, ketonuria and the acid--base status. However, HbA1c and C-peptide were significantly correlated. The elevated HbA1c-concentrations decreased towards normal in all of these 11 children after 2--3 months following adequate therapy. The results suggest that the determination of HbA1c may serve as a valuable metabolic control index in children with long-standing diabetes mellitus, but adds little information in newly diagnosed patients. For the individual diabetic child during the early treatment period, HbA1c may be the index of choice for adequacy of metabolic control.

References

Feb 9, 1984·The New England Journal of Medicine·D M NathanJ D Goodson
Jun 1, 1982·Archives of Disease in Childhood·N P Mann, D I Johnston
Nov 1, 1988·Acta paediatrica Scandinavica·G DahlquistS Wall
Jul 1, 1987·Acta paediatrica Scandinavica·S A IvarssonJ I Thorell
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·S Madsbad
May 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·H ArnqvistS Wettre

Citations

Mar 25, 1978·British Medical Journal·J Ditzel, J J Kjaergaard
Jul 1, 1978·Diabetes·K K GambhirC J Bradley
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K H GabbayP M Gallop
Jun 1, 1976·The Journal of Clinical Investigation·H F BunnP M Gallop
Oct 1, 1976·The Journal of Clinical Investigation·J F FitzgibbonsR T Jones
Aug 1, 1976·Klinische Wochenschrift·W BeischerE F Pfeiffer
Feb 1, 1973·Metabolism: Clinical and Experimental·E P Paulsen
Aug 22, 1969·Biochemical and Biophysical Research Communications·S RahbarH M Ranney

Related Concepts

C-Peptide
Ketosis
Glycosuria
Anion Gap
Diabetes, Autoimmune
Diabetes Mellitus
Hemoglobin A
Blood Glucose

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