Hemoglobin concentration; a pathway to frailty

BMC Geriatrics
Zara SteinmeyerSandrine Sourdet

Abstract

Frailty and hemoglobin concentration, above what would be considered clinical anemia, are two common findings in older patients that lead to an increased risk of negative health outcomes. The objective of this study is to evaluate whether hemoglobin concentration is an independent predictor of frailty and investigate possible causal pathways with a focus on the relationship between inflammation or nutrition and hemoglobin concentration. 1829 community-dwelling participants aged 65 years or older who visited the Toulouse frailty day hospital during 2011 and 2016 were included in this analysis. Patients underwent a comprehensive geriatric assessment and had a blood sample taken. A series of multivariate logistic regression models were performed after minimizing potential influence from age, gender, kidney function, inflammation, cognition, nutritional status and certain socio-economic factors. Hemoglobin concentration and frailty are significantly associated after minimizing potential influence from other covariates (p < 0.005). An increase in one point of hemoglobin concentration is associated with a 14% risk reduction of being frail (OR = 0.86, 95%IC = 0.79-0.94). There was no evidence of a significant causal relationship betwe...Continue Reading

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Citations

Dec 2, 2020·Lower Urinary Tract Symptoms·Alexander TamalunasGiuseppe Magistro
Mar 28, 2021·Revista española de geriatría y gerontología·José Luis Esquinas-RequenaPedro Abizanda
Apr 8, 2021·Acta Clinica Belgica·Osman KaraPinar Soysal
Jul 3, 2021·International Journal of Molecular Sciences·Chia-Ter Chao, Shih-Hua Lin
Nov 20, 2021·Journal of the American Geriatrics Society·Jack GuralnikWilliam J Evans

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Methods Mentioned

BETA
blood draw

Software Mentioned

STATA®
Gérontopôle Frailty Screeening

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Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

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