Hemoglobin concentration and cognitive impairment in the renal REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Manjula Kurella TamuraWilliam McClellan

Abstract

There is growing interest in determining the degree of anemia, which is clinically significant. The goal of this study was to determine the association between hemoglobin concentration and cognitive impairment in a large sample of U.S. adults. We used cross-sectional data from 19,701 adults participating in the REasons for Geographic And Racial Differences in Stroke study. Cognitive impairment was defined as a score of 4 or less on the six-item screener. Hemoglobin was analyzed in 1 g/dL increments relative to the World Health Organization (WHO) threshold (<13 g/dL for men and <12 g/dL for women). The mean hemoglobin concentration was 13.7 ± 1.5 g/dL. The prevalence of cognitive impairment increased from 4.3% among individuals with a hemoglobin >3 g/dL above the WHO threshold to 16.8% for those with a hemoglobin ≥2 g/dL below the WHO threshold. After adjustment for demographics, chronic health conditions, health status, and inflammation, the association between reduced hemoglobin and cognitive impairment was attenuated and no longer significant, including among those with hemoglobin ≥2 g/dL below the WHO threshold (odds ratio 1.39, 95% confidence interval = 0.94-2.04). A test for linear trend was of borderline significance (p v...Continue Reading

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Citations

Oct 10, 2012·American Journal of Hematology·Neil A ZakaiMary Cushman
Sep 13, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea L C SchneiderRebecca F Gottesman
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Dec 5, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·José Benedito R Valladão JúniorItamar S Santos

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