PMID: 2503042Aug 18, 1989Paper

Hemoglobin conversion to hemichrome under the influence of fatty acids

Biochimica Et Biophysica Acta
A A AkhremP A Kiselev

Abstract

The effect of free fatty acids on the process of hemoglobin conversion and lipid peroxidation has been studied in model systems and erythrocytes. It has been found that methemoglobin and oxyhemoglobin are converted to the low spin oxidized form, namely, reversible hemichrome under the action of fatty acids. In the case of oxyhemoglobin, an increase in the level of active oxygen forms is observed in the system which initiates the formation of primary and secondary lipid peroxidation products. Incubation of erythrocytes with free fatty acids causes the formation of Heinz bodies and is accompanied by an increase of the lipid peroxidation level.

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Sep 5, 1973·Journal of the American Chemical Society·R J Weinkam, E C Jorgensen
Jun 15, 1984·The Biochemical Journal·J SzebeniR W Carrell

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Citations

Nov 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S TúriB Matkovics
May 1, 1993·The International Journal of Biochemistry·J P HarringtonL Keaton
Jun 18, 2010·Meat Science·Cameron FaustmanSurendranath P Suman
Jul 30, 2015·Chemistry and Physics of Lipids·Lifan ShihThomas Jue
Aug 15, 1990·Archives of Biochemistry and Biophysics·D GalarisP Hochstein
Mar 31, 2017·Journal of Physiology and Biochemistry·Thomas JueRandall W Davis
Jul 20, 2016·Korean Journal for Food Science of Animal Resources·Ji-Han KimChi-Ho Lee
Jul 31, 1992·Biochimica Et Biophysica Acta·G ChottardG Herve
Dec 7, 2010·Colloids and Surfaces. B, Biointerfaces·Lidia Gebicka, Ewa Banasiak

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