Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro): a new unstable hemoglobin with twofold increased oxygen affinity

American Journal of Hematology
Philippe LacanHenri Wajcman

Abstract

Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro) is a new unstable variant, with high oxygen affinity responsible, in the steady state, for an apparently well-compensated chronic hemolytic anemia. The functional properties of this variant are due to the replacement of a leucine residue which is involved in the hydrophobic environment of the proximal side of the heme. This electrophoretically neutral hemoglobin was found as a de novo case in a 6-year-old girl suffering from severe anemia with hemolysis and transient aplastic crisis, following infection by parvovirus B19.

References

Feb 1, 1992·American Journal of Hematology·J W Harris
Jan 1, 1990·Hemoglobin·Y Ohba
Jan 1, 1988·Hemoglobin·P E Nute, G Stamatoyannopoulos
Jan 1, 1987·Acta Haematologica·C LacombeF Galacteros
Nov 1, 1972·British Journal of Haematology·R W Carrell, R Kay
May 15, 1984·Journal of Molecular Biology·G FermiR Fourme

❮ Previous
Next ❯

Citations

Jun 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Jamale Hacini, Joseph Watine
Mar 10, 2009·Blood Cells, Molecules & Diseases·Philippe JolyAlain Francina
Jul 1, 1997·Hemoglobin·P LacanA Lachaux
Aug 7, 2009·Hemoglobin·Peter van BalenShulamiet Wittebol
Dec 24, 2005·Hemoglobin·Philippe LacanAlain Francina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.