PMID: 25738296Mar 5, 2015Paper

Hemoglobin Degrading Proteases of Plasmodium falciparum as Antimalarial Drug Targets

Current Drug Targets
Tabish Qidwai

Abstract

Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases involved in human host hemoglobin degradation and other processes like erythrocyte invasion and rupture. Antimalarial drug resistance and natural selection in parasite are important reasons that create the urgent need of novel targets and lead compounds to overcome the burden of malaria. This report explored progress of the study covering proteases and their inhibitors specific to hemoglobin degradation. Additionally, in silico predicted antimalarial targets, balancing selection and drug-protein interaction are included.

Citations

Jun 6, 2016·Immunology Letters·Tabish Qidwai
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika R KarpinaLouis Maes

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