PMID: 701083Jan 1, 1978Paper

Hemoglobin Legnano (alpha2 141 (HC3) Arg replaced by Leu beta2): a new abnormal human hemoglobin with high oxygen affinity

Hemoglobin
F MavilioS Biagiotti

Abstract

An abnormal, fast moving hemoglobin was noted in a 34-yr-old male patient living in Legnano (northern Italy) affected with renal failure and iron deficiency anemia, not related to the presence of the Hb variant. Structural studies have demonstrated a previously undescribed amino acid substitution, alpha 141 Arg replaced by Leu. This new variant has been named Hb Legnano, and is characterized by an increased oxygen affinity and a low cooperativity, at least as far as preliminary functional studies carried out on whole blood have indicated. Family studies are reported: three other heterozygous carriers were observed among the relatives of the propositus, all showing a mild polycythemia which, however, does not seem to produce appreciable clinical consequences.

References

Nov 1, 1972·British Journal of Haematology·R W Carrell, R Kay
Apr 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·L TentoriC Buccella
May 1, 1970·Analytical Biochemistry·Z B Rose, J Liebowitz
Apr 26, 1969·Nature·J B CleggD Mustafa
Nov 1, 1965·Journal of Clinical Pathology·A J Marengo-Rowe
Apr 1, 1967·The Biochemical Journal·D Beale
Apr 1, 1961·Biochimica Et Biophysica Acta·C BAGLIONI
Dec 12, 1959·Nature·K BETKEI SCHLICHT

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Citations

Jun 19, 1979·Biochimica Et Biophysica Acta·M MarinucciL Tentori

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