Hemoglobin mass and intravascular volume kinetics during and after exposure to 3,454-m altitude

Journal of Applied Physiology
C SiebenmannCarsten Lundby

Abstract

High altitude (HA) exposure facilitates a rapid contraction of plasma volume (PV) and a slower occurring expansion of hemoglobin mass (Hbmass). The kinetics of the Hbmass expansion has never been examined by multiple repeated measurements, and this was our primary study aim. The second aim was to investigate the mechanisms mediating the PV contraction. Nine healthy, normally trained sea-level (SL) residents (8 males, 1 female) sojourned for 28 days at 3,454 m. Hbmass was measured and PV was estimated by carbon monoxide rebreathing at SL, on every 4th day at HA, and 1 and 2 wk upon return to SL. Four weeks at HA increased Hbmass by 5.26% (range 2.5-11.1%; P < 0.001). The individual Hbmass increases commenced with up to 12 days of delay and reached a maximal rate of 4.04 ± 1.02 g/day after 14.9 ± 5.2 days. The probability for Hbmass to plateau increased steeply after 20-24 days. Upon return to SL Hbmass decayed by -2.46 ± 2.3 g/day, reaching values similar to baseline after 2 wk. PV, aldosterone concentration, and renin activity were reduced at HA (P < 0.001) while the total circulating protein mass remained unaffected. In summary, the Hbmass response to HA exposure followed a sigmoidal pattern with a delayed onset and a plateau ...Continue Reading

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Citations

Sep 5, 2015·The Journal of Physiology·Robert A JacobsCarsten Lundby
Feb 26, 2016·Experimental Physiology·Benjamin J RyanWilliam C Byrnes
Jul 12, 2016·International Journal of Cardiology·David MonteroCarsten Lundby
Dec 15, 2016·The Journal of Physiology·Christoph SiebenmannCarsten Lundby
Mar 10, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Stefanie KeiserCarsten Lundby
Jan 31, 2017·Clinical Physiology and Functional Imaging·Nazzareno FagoniCarsten Lundby
Jan 19, 2018·Exercise and Sport Sciences Reviews·Jacob Bejder, Nikolai Baastrup Nordsborg
Feb 23, 2018·Scandinavian Journal of Medicine & Science in Sports·P RobachC Lundby
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Apr 22, 2017·Journal of Applied Physiology·Angela Fago
Jun 3, 2017·Journal of Applied Physiology·Christoph SiebenmannCarsten Lundby
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Jun 17, 2016·Medicine and Science in Sports and Exercise·Christoph Siebenmann
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