PMID: 514Nov 1, 1975

Hemoglobin solution and the oxyhemoglobin dissociation curve

The Journal of Trauma
A G GreenburgG W Peskin

Abstract

1) A study was carried out to determine the oxyhemoglobin dissociation curve of stroma-free hemoglobin solution and factors which influence it, (pH; 2,3 DPG). 2) To simulate acute volume replacement, dilution experiments, in vitro, were performed employing both hemoglobin solution and Ringer's lactate in whole blood. 3) It was determined that stroma-free hemoglobin solution has a left-shifted oxyhemoglobin dissociation curve which responds to pH change but not to the addition of 2,3 DPG. 4) The dilutional effect of hemoglobin solution when mixed with whole blood in volumes up to 50% was to left-shift the oxyhemoglobin curve, unlike the effect of Ringer's lactate (no change). 5) This may have importance in the hemodynamic compensatory response to acute normovolemic anemia.

Citations

Feb 1, 1977·The Journal of Surgical Research·K A GinsburgG W Peskin
Oct 26, 2013·The Journal of Trauma and Acute Care Surgery·Donald S Gann, William R Drucker
May 9, 2000·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·H I FriedmanR Bynoe

Related Concepts

Blood Preservation
Diphosphoglyceric Acids
Eryhem
Hydrogen-Ion Concentration
Lactates
Oxyhemoglobin
Resuscitation Procedure

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Proceedings of the Society for Experimental Biology and Medicine
S UsamiM I Gregersen
© 2021 Meta ULC. All rights reserved