Hemoglobin spray as adjunct therapy in complex wounds: Meta-analysis versus standard care alone in pooled data by wound type across three retrospective cohort controlled evaluations

SAGE Open Medicine
Fredrik Elg, Sharon D Hunt

Abstract

Low tissue oxygenation is a predictor of healing outcomes in complex wounds. Adjunct hemoglobin to aid oxygen diffusion has been demonstrated to achieve superior healing outcomes; however, the relative healing benefit across different wound types and evaluations has not yet been estimated. This article does this for the first time. Data were pooled from previously published real world controlled evaluations, three retrospective cohort controlled studies of a variety of wounds within standard care across hospital and primary care in the North of England in patients with diabetic foot ulcers (n = 40), chronic wounds (n = 100), and sloughy wounds (n = 200). Wounds were equally distributed between adjunct hemoglobin and control and the hemoglobin spray was used as per instructions for use and applied twice weekly, mostly for the duration of the wounds in all three evaluations. Wound healing over 26 weeks was the primary outcome in each of the evaluations, with additional healing and quality of life indicators including pain, wound size, slough coverage, wound exudate levels, adverse events, and dressing regimen used, over time. Each wound type with 10 or more patients in both the standard care alone and adjunctive hemoglobin groups...Continue Reading

References

Feb 26, 1960·Science·P F SCHOLANDER
Jul 5, 2007·BMC Medical Research Methodology·Rob McCarneyPeter Fisher
Jan 24, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Matthew CardinalKeith Harding
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chandan K Sen
Jan 29, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ArenbergerovaP Arenberger
Nov 10, 2015·Journal of Wound Care·S L Percival, L Suleman

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Citations

Mar 7, 2019·Journal of Wound Care·Judith Cj HolzerLars-Peter Kamolz
May 20, 2020·Journal of Wound Care·John Lantis
May 20, 2020·Journal of Wound Care·Johnson Boey
May 20, 2020·Journal of Wound Care·Johnson Boey
May 20, 2020·Journal of Wound Care·Harikrishna Kr Nair
May 20, 2020·Journal of Wound Care·Linda Hicks
May 20, 2020·Journal of Wound Care·Ibby Younis
Aug 18, 2020·Journal of Wound Care·Kengkart WinaikosolAjanee Mahakkanukrauh

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