Hemoglobin-Strumica or alpha 2 112(G19) His replaced by Arg beta 2. (With an addendum: hemoglobin-J-Paris-I, alpha 2 12(A10) Ala replaced by Asp beta 2, in the same population).

Biochimica Et Biophysica Acta
G A NiaziT H Huisman

Abstract

Hemoglobin-Strumica has been observed in five members of a Macedonian family. Histidyl residue in position 112 of the alpha chain of this variant is replaced by an arginyl residue. Two other variants (hemoglobin-Dakar and hemoglobin-Hopkins-2) in which this histidyl residue has been replaced by a glutaminyl and by an aspartyl residue, respectively, have been described (Rosa et al. (1968) 12 thCongr. Int. Soc. Haematol. New York, abstract, p. 73 and Charache, S. and Osterag, W. (1970) Bloodt 36, 852). The hemoglobin-Strumica heterozygotes have minimal hematological changes although this may not necessarily be associated with the hemoglobinopathy. Subjects heterozygous for hemoglobin-Dakar have a mild hemolytic anemia and hemoglobin-Hopkins-2 heterozygotes exhibit minimal hematological changes.

References

Oct 9, 1974·Biochimica Et Biophysica Acta·F VellaT J Huisman
Nov 1, 1972·British Journal of Haematology·R W Carrell, R Kay
Jan 1, 1968·Acta Haematologica·C TrincaoH Lehmann
Nov 1, 1971·The Journal of Clinical Investigation·M M KeelingT H Huisman
Dec 22, 1971·Nature: New Biology·S CharacheG von Ehrenstein
Dec 12, 1959·Nature·K BETKEI SCHLICHT
Jan 1, 1963·Advances in Clinical Chemistry·T H HUISMAN
Mar 20, 1930·The Journal of General Physiology·M L Anson, A E Mirsky

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Citations

Jan 1, 1992·Hemoglobin·G D Efremov
Jan 1, 1982·Hemoglobin·G D EfremovN Stojanovski
Jan 1, 1980·Hemoglobin·D Labie
Jan 1, 1985·Hemoglobin·Y OhbaM Sakuragawa

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