Hemoglobinopathies in North Africa: a review

Hemoglobin
Amel Haj KhelilPascale Perrin

Abstract

Hemolytic anemias are very common diseases. Among these diseases, hemoglobinopathies are widely spread throughout the Mediterranean Basin, including North Africa (Tunisia, Algeria and Morocco). Their severity and disabling nature make them a major public health problem. This study includes our data on the Tunisian hemoglobinopathies together with all the reports concerning epidemiological, clinical and molecular aspects in Algerian and Moroccan populations. Investigation methods begin with the application of several techniques for hemoglobin (Hb) analyses [electrophoresis and isoelectric focusing (IEF), micro-chromatography assay] of anemic patients in various hospital departments. Molecular investigation by DNA analyses completes the hematological and biochemical studies using polymerase chain reaction (PCR) followed by enzymatic digestion and/or denaturing gradient gel electrophoresis (DGGE), single strand conformation polymorphism (SSCP) and sequencing. These methods offer screening for a large number of families affected by sickle cell disease and thalassemia. In Tunisia, Algeria, and Morocco, more than 45 mutations have been identified on the beta-globin gene. The most common in Tunisia and in Algeria are codon 39 (C>T) an...Continue Reading

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y W Kan, A M Dozy
Mar 1, 1987·Human Genetics·T HenniJ Godet
Jan 1, 1987·Hemoglobin·S Fucharoen, P Winichagoon
Feb 1, 1988·Human Genetics·J ChibaniM Goossens
Mar 1, 1981·The Journal of Clinical Investigation·S H OrkinD G Nathan
Jul 1, 1982·The New England Journal of Medicine·S H OrkinC D Boehm
Jan 1, 1983·Human Genetics·C BeldjordD Labie
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J PagnierD Labie
Jan 1, 1994·Hemoglobin·B ChamiF Galactéros
Nov 1, 1996·British Journal of Haematology·T N WilliamsD K Bowden
Mar 1, 1997·Human Genetics·M FicheraA Ragusa
Mar 12, 1998·American Journal of Hematology·G O TadmouriA N Başak
Jun 10, 1998·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M FrikhaH Ayadi
Feb 10, 2000·Molecular Biology and Evolution·S M FullertonJ B Clegg
Mar 8, 2000·American Journal of Hematology·G O TadmouriA N Başak
Jun 27, 2003·American Journal of Hematology·Wafaa LemsaddekLeonor Osório-Almeida
Aug 9, 2003·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M J HajjeJ Haddad

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Citations

Dec 12, 2012·Journal of Community Genetics·Hanan A Hamamy, Nasir A S Al-Allawi
Aug 23, 2012·Orphanet Journal of Rare Diseases·Lilia RomdhaneSonia Abdelhak
Dec 27, 2011·The Indian Journal of Medical Research·Mohsen A F El-HazmiArjumand S Warsy
Jan 7, 2014·Revue D'épidémiologie Et De Santé Publique·M N AloniF Kittel
May 27, 2015·Clinical Genetics·L RomdhaneS Abdelhak
Dec 20, 2014·Hemoglobin·Rakesh KumarPurnima Kishor
May 21, 2011·Blood Reviews·Barbara J Bain
Mar 2, 2012·Clinical Genetics·H López-EscribanoA Picornell
Jun 7, 2014·International Journal of Laboratory Hematology·A ZoraiS Abbes
Mar 3, 2015·International Journal of Clinical Practice·A GiambonaA Maggio
Aug 11, 2017·Journal of Clinical Pathology·Margherita VinciguerraAntonino Giambona
Jan 24, 2019·Hemoglobin·Hossam MuradYasser Mukhalalaty
Aug 12, 2014·European Journal of Public Health·Wagida A AnwarKari Hemminki
Jun 9, 2020·Hemoglobin·Fatima-Zahra Alaoui-IsmailiMohcine Bennani-Mechita
Nov 21, 2018·Clinical Case Reports·Wafaa BouyarmaneSamira El Machtani Idrissi
Apr 18, 2018·Molecular Genetics & Genomic Medicine·Houda Elloumi-Zghal, Habiba Chaabouni Bouhamed
Apr 20, 2019·BioMed Research International·Achraf LaghmichMohcine Bennani Mechita

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