PMID: 5917784Sep 23, 1966

Hemoglobins in sheep: multiple differences in amino acid sequences of three beta-chains and possible origins

S H BoyerM A Naughton


Among the three adult sheep hemoglobins (A, B, and C), two (A and B) are reportedly products of alleles. The beta-chains of A and B differ by at least seven scattered amino acid residues whereas the beta-sequence of C differs from A by at least 16 residues and from B by at least 21 residues. These changes suggest that the origin of C-beta antedated the divergence of A and B. Five shared differences between A-beta and C-beta with respect to B-beta can be interpreted as the result of selective advantage in favor of B. A complex of additional mechanisms has possibly been involved in maintaining the A-B- C porymorphism.


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Related Concepts

Blood Protein Electrophoresis
Chemistry Techniques, Analytical
Dall Sheep

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