PMID: 6538181Jan 1, 1984Paper

Hemoglobins S and C in Upper Volta

Human Genetics
D LabieR L Nagel

Abstract

We have studied the incidence of hemoglobinopathies in 1059 individuals in Upper Volta. We have found that this population has a high frequency of HbS and HbC and alpha-thalassemia. The gene frequency of HbS was high (0.1 for the beta s gene) in the arid Sahel portion of Upper Volta accompanied by a lower frequency for HbC (0.05 for the beta c gene). The reverse was true in the humid Savanna region of this country (0.03 for the beta s gene and 0.14 for the beta c gene). There was no age dependency of the HbS gene frequency, but alpha-thalassemia, detectable in HbS heterozygotes, showed a statistically significant decrease with age. No homozygote for HbS was detected after the age of 1 year, and SC and CC genotypes were found at a lower incidence than expected. The environmental and medical conditions in Upper Volta preclude the survival of SS individuals and decrease the survival of SC and CC genotypes.

References

Feb 1, 1979·Experimental Parasitology·M J FriedmanW Trager

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Citations

Aug 31, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ina DanquahFrank P Mockenhaupt
Jun 24, 2003·Blood Reviews·Ronald L NagelMartin H Steinberg
Jul 1, 1991·Annals of Human Biology·R DevoucouxJ Feingold
May 1, 1989·British Journal of Haematology·A Van EnkM Bos-Keijning
Feb 26, 2015·The Journal of Infectious Diseases·Valentina D ManganoUNKNOWN MalariaGEN Consortium
Dec 7, 2011·American Journal of Preventive Medicine·Scott D GrosseThomas N Williams
Jan 12, 1999·American Journal of Hematology·M B ChaseP E Berg
Jul 1, 1994·American Journal of Hematology·R DucrocqA Chaventre

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