Hemolysin is required for extraintestinal dissemination of Listeria monocytogenes in intragastrically inoculated mice.

Infection and Immunity
J T Roll, C J Czuprynski

Abstract

In this study we demonstrated that a hemolytic strain of Listeria monocytogenes, but not a nonhemolytic mutant derived from it, translocated in substantial numbers to the mesenteric lymph nodes, spleen, and liver after intragastric inoculation of mice. Growth at 4 degrees C prior to inoculation did not increase the virulence of the nonhemolytic mutant. These results indicate that hemolytic activity is required for the virulence of L. monocytogenes via the gastrointestinal tract, as has been shown previously for parenteral challenge.

References

Apr 1, 1988·The Journal of Experimental Medicine·D A PortnoyD J Hinrichs
May 1, 1970·Applied Microbiology·J K Miller, J Burns
Apr 1, 1981·Infection and Immunity·C J Czuprynski, E Balish

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Citations

Jun 1, 2002·Applied and Environmental Microbiology·Charles J CzuprynskiHoward Steinberg
Aug 23, 2003·Infection and Immunity·Terri S HamrickPaul E Orndorff
Jan 1, 1997·Critical Reviews in Microbiology·A K Bhunia
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·C J Czuprynski, N G Faith
Dec 5, 2018·Cellular Microbiology·Brittney N NguyenDaniel A Portnoy
Mar 21, 1998·Microbial Pathogenesis·A J MarcoV Briones
Aug 1, 1991·Applied and Environmental Microbiology·S A McCarthy
Aug 28, 2007·Microbes and Infection·Marc Lecuit

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