Hemolysis following platelet transfusions from ABO-incompatible donors

R N PierceK Mayer


Two hemolytic transfusion reactions related to isoagglutinins present in group O platelet concentrates are reported. The first, a severe reaction in a group A 10-kg patient, resulted from transfusion of 200 ml of plasma containing a hemolytic anti-A, titer 16, and an IgG anti-A, titer of 32,000. In the second case, a group B adult received between 50 and 70 ml of O plasma with a titer (16,000) of anti-B. This was followed by hemolysis of approximately 40 percent of the patient's red cell volume.


Sep 19, 2002·American Journal of Therapeutics·Heather A Hume, Pierre Limoges
Jan 15, 1999·BMJ : British Medical Journal·J K DuguidP H Bolton-Maggs
Jun 1, 1988·Transfusion Medicine Reviews·R G Strauss, R A Sacher
Apr 21, 2010·Best Practice & Research. Clinical Anaesthesiology·Bruce D Spiess
Dec 26, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Cassandra D JosephsonChristopher D Hillyer
Aug 7, 2007·Lancet·David F Stroncek, Paolo Rebulla
Jul 26, 2003·Transfusion Medicine·M L Barjas-CastroV Castro
Nov 3, 2005·Journal of Clinical Apheresis·Suneeti SapatnekarRoslyn Yomtovían
Apr 25, 2007·Acta Clinica Belgica·A BoslyD Sondag
Mar 15, 2012·Transfusion·Magali J FontaineLawrence T Goodnough
Jan 1, 1989·Clinical and Laboratory Haematology·M D Reis, A S Coovadia
Jul 16, 2015·Transfusion·Willy A Flegel
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Tamara R BelinAndrew P Cap
Nov 4, 2017·Anesthesia and Analgesia·Majed A RefaaiNeil Blumberg
Jan 9, 2020·Transfusion·Natalie MalvikC Michael Knudson
Apr 17, 2004·Journal of Pediatric Hematology/oncology·Anne Angiolillo, Naomi L C Luban
Jun 18, 1991·Klinische Wochenschrift·D Söhngen, W Schneider
Jun 7, 2007·Archives of Pathology & Laboratory Medicine·Mark K FungIra A Shulman

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.