PMID: 37415Jan 1, 1979

Hemolytic activity of a togavirus, Getah

Microbiology and Immunology
Y YoshinakaT Shiomi

Abstract

A purified toga-alphavirus, Getah (GET), showed optimal hemolytic activity for one-day-old chick red blood cells when incubated at 37 C for 120 min at pH 6.2. Experimental data obtained from various angles, such as pH dependency, inhibition by virus-specific antiserum and by concanavalin A, indicated that the hemolysis was a property of the virus particle itself. Although the mechanism of hemolysis by togaviruses has not been known, our results indicated that viral lipids may participate in this activity since the hemolytic activity was impaired by delipidation procedures.

References

Feb 1, 1975·Journal of Virology·J J MooneyP K Russell
Mar 1, 1975·Journal of Virology·Y Yoshinaka, T Shiomi
Jan 1, 1973·Archiv für die gesamte Virusforschung·N Karabatsos
Oct 15, 1973·Journal of Molecular Biology·K SimonsH Garoff
Mar 1, 1974·The Journal of General Virology·W W Hall, S J Martin
May 1, 1972·Virology·S SchlesingerB W Burge
Jul 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·Y Yoshinaka, S Hotta
Sep 1, 1958·The American Journal of Tropical Medicine and Hygiene·D H CLARKE, J CASALS
Feb 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·N KARABATSOS

Citations

Jan 1, 1983·Archives of Virology·N KobayashiM Matumoto

Related Concepts

Arboviruses
Calcium Chloride, Anhydrous
Concanavalin A
Synthetic Detergent
Erythrocytes
Hemolysis
Hydrogen-Ion Concentration
Immune Sera
Panzytrat
Solvents

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