Hemolytic Disease of the Fetus and Newborn Caused by Maternal Autoantibody with Mimicking Anti-E Specificity.

Laboratory Medicine
Xueni ChenYongmei Jiang

Abstract

There are few reports of hemolytic disease of the fetus and newborn (HDFN) caused by maternal autoantibodies. We describe the case of a pregnant patient aged 26 years with systemic lupus erythematosus without any transfusion history who developed autoantibody with mimicking anti-E specificity. Her newborn developed HDFN caused by the maternal autoantibody. The clinical symptoms of the newborn were not serious. After bilirubin light phototherapy and other symptomatic supportive treatment, the baby was discharged with a good prognosis. This is the first reported case of HDFN caused by maternal autoantibody with mimicking anti-E specificity. However, the real antigenic target of the autoantibody was not clear.

References

Jan 5, 2002·Transfusion·B HoppeA Salama
Aug 21, 2004·Transfusion·Denis M DwyreRonald G Strauss
Aug 27, 2009·Transfusion Medicine·J DaviesS Simpson

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