Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones

The Journal of Clinical Investigation
K L MelmonS Bauminger


Histamine, beta-adrenergic amines, and prostaglandins inhibited hemolytic plaque formation by splenic leukocytes from immunized mice. The same agents had previously been shown to prevent both the IgE-mediated release of histamine from human basophils and the immunologically specific cytolytic activity of murine lymphocytes, through stimulation of the production of cyclic AMP in leukocytes. We therefore tested the hypothesis that cyclic AMP might mediate an inhibitory effect of these drugs by comparing the ability of these agents to inhibit plaque formation with their effects on cyclic AMP accumulation in leukocytes. In splenic cells from three mouse strains, the dose-dependent effects of these agents of cyclic AMP correlated with their inhibition of plaque formation. Beta- but not alpha-adrenergic agonists were effective in both systems, and the effects of isoproterenol were inhibited by propranolol. Histamine was approximately equipotent with isoproterenol in both systems. Two prostaglandins (E(1) and E(2)) were effective in both systems, but prostaglandin F(2alpha) was not. Dibutyryl cyclic AMP, a lipid-soluble analog of the endogenous nucleotide, inhibited plaque formation by cells of all three strains. Theophylline, an inhi...Continue Reading


Aug 30, 1968·Science·L M Lichtenstein, S Margolis
Apr 29, 1969·Biochemical and Biophysical Research Communications·S M Wolfe, N R Shulman
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jan 1, 1974·The Journal of Clinical Investigation·K L MelmonS Bauminger
Nov 1, 1972·The Journal of Experimental Medicine·G M ShearerM Sela
May 1, 1970·The Journal of Infectious Diseases·R A Finkelstein, J J LoSpalluto
Feb 10, 1967·Annals of the New York Academy of Sciences·G A RobisonE W Sutherland
Feb 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·G R McKinney, P M Lish

❮ Previous
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Mar 1, 1982·Calcified Tissue International·T Yoneda, G R Mundy
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Dec 14, 2011·Amino Acids·Franca Marino, Marco Cosentino
May 1, 1978·Cellular Immunology·K D GrinwichJ Cerny
Apr 1, 1981·Cellular Immunology·Y ThomasD Granjon
Jan 1, 1996·Life Sciences·J M Green-JohnsonA H Greenberg
Jan 1, 1981·Toxicon : Official Journal of the International Society on Toxinology·W HryniewiczJ Jeljaszewicz
Oct 1, 1982·Molecular Immunology·E Kownatzki
Apr 1, 1980·Immunopharmacology·R D Peterson, G C Palmer
Nov 1, 1993·Journal of Neuroimmunology·C M DobbsJ F Sheridan
Jan 1, 1980·International Journal of Immunopharmacology·H van DijkJ M Willers
Jan 1, 1981·International Journal of Immunopharmacology·B E LovelandI F McKenzie
Jan 1, 1982·International Journal of Immunopharmacology·S Nicklin, F L Shand
Jan 1, 1984·International Journal of Immunopharmacology·K MilesE Chelmicka-Schorr
Jan 1, 1984·International Journal of Immunopharmacology·S W BurchielN L Warner
Jan 1, 1985·International Journal of Immunopharmacology·N K NandaI Nath
Jan 1, 1991·International Journal of Immunopharmacology·H StepienM Pawlikowski
Sep 1, 1994·International Journal of Immunopharmacology·N GorenE Borda
Nov 1, 1990·Peptides·D LortonD L Felten
Nov 1, 1983·Prostaglandins, Leukotrienes, and Medicine·K KatoS Murota
Oct 9, 1975·Biochimica Et Biophysica Acta·T V Zenser
Dec 30, 1988·Biochemical and Biophysical Research Communications·E W JohnsonE M Smith
Jul 4, 1981·Lancet
Nov 30, 2000·Immunology Today·A P Kohm, V M Sanders
Feb 6, 1975·The New England Journal of Medicine·R Carmel
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·O J PlesciaK Grinwich
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C F BrosnanW T Norton
Oct 1, 1974·The Journal of Experimental Medicine·F V Chisari, T S Edgington
Nov 1, 1977·The Journal of Experimental Medicine·A M Tartakoff, P Vassalli

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