PMID: 11899496Mar 20, 2002Paper

Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

Revue médicale de Liège
C MassetG Rorive

Abstract

Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies (TMA). Both familial and sporadic forms exist: anaemia, thrombopaenia, renal failure and neurologic disorders are common clinical features. The differential diagnosis depends on plasma levels of von Willebrand factor-cleaving protease: there is a deficiency of this protease in patients with TTP whereas its rate is normal in HUS. We remind pathophysiology, etiologies and treatment of these TMA.

Citations

Nov 13, 2001·Reviews in Clinical and Experimental Hematology·T Raife, R Montgomery

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