Hemolytic uremic syndrome in adults: A case report

World Journal of Critical Care Medicine
Fabiel Gerardo Pérez-CruzMaría Pérez-Fernández

Abstract

Thrombotic microangiopathies (TMA) are microvascular occlusive disorders characterized by platelet aggregation and mechanical damage to erythrocytes, clinically characterized by microangiopatic haemolytic anemia, thrombocytopenia and organ injury. We are reporting a case of a woman patient with severe hemolytic uremic syndrome associated to infectious diarrhoea caused by Shiga toxin-producing pathogen, who were admitted to our intensive care unit. The patient described developed as organ injury, neurological failure and acute renal failure, with need of haemodialysis technique. Due to the severity of the case and the delay in the results of the additional test that help us to the final diagnose, we treated her based on a syndromic approach of TMA with plasma exchange, with favourable clinical evolution with complete recovery of organ failures. We focus on the syndromic approach of these diseases, because thrombotic thrombocytopenic purpura, one of the disorders that are included in the syndromes of TMA, is considered a haematological urgency given their high mortality without treatment; and also review the TMA in adults: Their pathogenesis, management and outcomes.

References

Aug 23, 2002·The New England Journal of Medicine·Joel L Moake
May 27, 2011·The New England Journal of Medicine·Anne-Laure LapeyraqueFranz Schaefer
May 26, 2012·British Journal of Haematology·Marie ScullyUNKNOWN British Committee for Standards in Haematology
Jun 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sebastian LoosMarkus J Kemper
Nov 6, 2014·The New England Journal of Medicine·James N George, Carla M Nester
Dec 1, 2014·Medicina clínica·Miquel Blasco PelicanoJosep M Campistol Plana
Dec 1, 2014·Medicina clínica·Enric ContrerasUNKNOWN por el Grupo Español de Aféresis
Jan 13, 2015·F1000prime Reports·David KavanaghNeil S Sheerin
Oct 13, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Josep M CampistolSantiago Rodríguez de Córdoba
Nov 7, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Emanuel FerreiraMário Campos

❮ Previous
Next ❯

Citations

Feb 25, 2020·The Journal of International Medical Research·Jun HuangTing Tan

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.