PMID: 8611362Feb 1, 1996Paper

Hemolytic uremic syndrome in families-an Argentinian experience

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
L E VoyerS Corti

Abstract

Six hundred and thirty-one patients with hemolytic uremic syndrome (HUS) were treated from 1960 to 1992; 19 (3%) were familial cases, of which 9 were classified as concomitant (including twins), 6 as non-concomitant, and 4 as recurrent. In the recurrent group there were 15 HUS episodes, 10 being concomitant in 2 patients. Prodromal diarrhea was present only in concomitant and non-concomitant cases. Patients with recurrences were sisters from a single family. Concomitant and non-concomitant cases had clinical features, course, and age similar to typical endemoepidemic forms of HUS, in which an association with verocytotoxin-producing Escherichia coli has been reported. There may be a genetic determinant in concomitant cases; these occurred outside the season during which endemoepidemic forms are typically detected. In patients with recurrent disease a genetic factor which may lead to the development of the disease when triggered by viral infections is likely.

References

Apr 27, 1978·The New England Journal of Medicine·B S Kaplan, K N Drummond
Mar 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J ZachwiejaJ Maciejewski
May 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B S KaplanT G Obrig
Sep 1, 1989·The Journal of Infectious Diseases·E L LopezM Vasquez
Jul 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A A NovilloN Binztein

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Citations

Apr 6, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alejandro BalestracciRaquel Eva Wainsztein
Jun 27, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eva JablonkaDaniel Dor

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