Hemolytic uremic syndrome with intracranial hemorrhage following mitomycin C administration

Internal Medicine
Y NishiyamaY Katayama

Abstract

A 50-year-old woman treated for breast cancer with mitomycin C developed severe hypertension, followed by deep coma 3 days later. Computed tomography of the brain showed frontoparietal intracranial hemorrhage accompanied by subarachnoid hemorrhage. The patient was diagnosed additionally with hemolytic uremic syndrome (HUS) based on hemolytic anemia with schistocytosis, thrombocytopenia, and acute renal failure. The patient underwent hemodialysis and plasmapheresis with no improvement. We present the pathologic findings of the general vessels, which has been reported rarely. This case represents the first reported intracranial hemorrhage in HUS following mitomycin C administration. We emphasize the need to control blood pressure in patients with HUS.

Citations

Nov 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin KreuzerLars Pape
Jul 17, 2004·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Jeffrey S DlottLeo J McCarthy
Nov 29, 2005·International Journal of Experimental Pathology·Gemma MolyneuxJohn A Turton
May 31, 2021·Bulletin du cancer·Marion Alhenc-Gelas, François-Clément Bidard

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