PMID: 111596Aug 1, 1979

Hemoperfusion to treat intoxications

Annals of Internal Medicine
J Lorch, S Garella

Abstract

Hemoperfusion is being increasingly proposed and used for the treatment of a large variety of exogenous intoxications. This procedure has been shown to achieve high clearance rates of most common intoxicants, and case reports have claimed that its application has been, on occasion, life-saving. We tabulated our experience in the treatment of 94 consecutive patients with severe intoxications who were treated with supportive management only; this group constituted 25% of all patients admitted with a diagnosis of drug overdose. Of the 94 patients only one died; all others were discharged without sequelae resulting from the intoxication or its complications; only 21% required more than a 48-hour stay in the intensive care unit. We propose that supportive management must remain the mainstay of therapy even in severely intoxicated patients; with few exceptions, hemoperfusion must be considered an as yet unproven form of therapy; further controlled studies are necessary to establish its range of indications, potential benefits, and cost effectiveness.

Citations

Apr 1, 1993·Journal of General Internal Medicine·M D SteinT J Wachtel
Aug 20, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Sayandeep JanaSuresh Ramasubban
Jan 1, 1981·Clinical and Experimental Dialysis and Apheresis·S B SmithR Venkatesan
Oct 1, 1980·Clinical Toxicology·E G Comstock
Nov 1, 1980·Clinical Toxicology·S Garella, J Lorch
Jul 1, 1987·Medical Toxicology and Adverse Drug Experience·A Heath, K Knudsen
Mar 12, 2003·Chest·Babak MokhlesiThomas C Corbridge
Mar 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J F Winchester
Mar 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E BlyeS Cortell
Jan 1, 1981·Annals of Emergency Medicine·A R Soslow
Nov 1, 1986·Annals of Emergency Medicine·T AnthonyH Prasad
Jun 1, 1982·Annals of Emergency Medicine·J A Sharff, M J Bayer
Jan 1, 1985·The American Journal of Medicine·R L Slaughter, R E DuPuis
Mar 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·V R Beasley, D C Dorman
Feb 1, 1986·Acta Anaesthesiologica Scandinavica·J StrømM Bredgaard Sørensen
Oct 1, 1982·Human Toxicology·A HeathJ Ahlmén
Jan 1, 1980·Acta Medica Scandinavica·A HeathJ Ahlmén

Related Concepts

Cost Effectiveness
Hemoperfusion
Poisoning

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