Hemopexin is up-regulated in plasma from type 1 diabetes mellitus patients: Role of glucose-induced ROS

Journal of Proteomics
Chia-Ching ChenHong-Lin Chan

Abstract

Type 1 diabetes mellitus (T1DM) is an insulin-dependent metabolic disease in the world and often occurs in children and adolescents. Recent advances in quantitative proteomics offer potential for the discovery of plasma proteins as biomarkers for tracking disease progression and for understanding the molecular mechanisms of diabetes. Comparative proteomic analysis of the plasma proteomes from T1DM cases and healthy donors with lysine- and cysteine-labeling 2D-DIGE combining MALDI-TOF/TOF mass spectrometry revealed that 39 identified T1DM-associated plasma proteins showed significant changes in protein expression including hemopexin, and 41 in thiol reactivity. Further study showed that hemopexin can be induced in numerous cell lines by increasing the glucose concentration in the medium. Interestingly, glucose-induced hemopexin expression can be reduced by reactive oxygen species (ROS) scavengers such as glutathione, implying that hemopexin expression is linked to glucose-induced oxidative stress. In conclusion, the current work has identified potential T1DM biomarkers and one of these, hemopexin, can be modulated by glucose through a ROS-dependent mechanism.

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Citations

Dec 12, 2012·Biomarkers in Medicine·Francesco Di GirolamoLorenza Putignani
Sep 10, 2013·The Journal of Nutritional Biochemistry·Jing-Yi ChenHong-Lin Chan
Mar 17, 2015·Mutation Research·Caterina GiovanniniRoberto Scarpato
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yi-Wen ChenHong-Lin Chan
Sep 24, 2013·Molecular BioSystems·Sompop BencharitJohn B Buse
Nov 17, 2016·Omics : a Journal of Integrative Biology·Camila Pereira BragaPedro de Magalhães Padilha
Sep 10, 2020·Disease Markers·Zhiying HuMan Zhang
Jul 25, 2021·Journal of Clinical Medicine·Agnieszka Pukajło-Marczyk, Danuta Zwolińska

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