Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature

Journal of Infection in Developing Countries
Maria ScalzoneRiccardo Riccardi

Abstract

Hemophagocytic lymphohistiocytosis is a potentially fatal disorder resulting from excessive activation and non-malignant proliferation of T lymphocytes and macrophages. Neoplasms, autoimmune disorders and systemic infections can cause secondary hemophagocytic syndrome. The association of hemophagocytic syndrome and visceral leishmaniasis is rarely found in childhood.  We report a case of an infant affected by hemophagocytic lymphohistiocytosis secondary to visceral leishamniasis and describe all cases of hemophagocytic syndrome associated with visceral leishamniasis in childhood reported in literature, focusing on clinical manifestation, diagnosis and treatment.

Citations

Jul 16, 2019·BMJ Case Reports·Pawan Kumar Singh, Vishal Sharma
Sep 2, 2016·Journal of Tropical Pediatrics·Nowneet Kumar BhatSmita Chandra
Jun 5, 2020·Indian Journal of Pediatrics·Rishi BoliaPrateek Kumar Panda
Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Fernando Henrique Guimarães de CarvalhoSílvio Fernando Guimarães de Carvalho
Jun 1, 2020·Enfermedades infecciosas y microbiología clínica·Jon BadiolaJosé Hernández-Quero
Feb 5, 2021·The Pediatric Infectious Disease Journal·María López MarcosUNKNOWN GAIP (Grupo Andaluz de Infectología e Inmunopatología Pediátrica) Network
Aug 12, 2021·Therapeutic Advances in Infectious Disease·Gerardine García OronozJosé A Suarez

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