Hemophagocytic Lymphohistiocytosis in a Newborn Presenting as "Blueberry Muffin Baby"

Pediatric Dermatology
Krista N LarsonDean S Morrell

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterized by uncontrolled activation and proliferation of proinflammatory cytokines. Initial presentation commonly includes fever, hepatosplenomegaly, and pancytopenia; 6 to 65% of cases also have a concurrent cutaneous eruption. We present the case of a 6-day-old premature infant boy with congenital severe thrombocytopenia, anemia, and hepatosplenomegaly who presented with several cutaneous violaceous papules and nodules and was found to have HLH.

References

Apr 1, 1991·Acta paediatrica Scandinavica·J I HenterA Ost
Jun 1, 1989·Journal of the American Academy of Dermatology·J B BowdenR P Rapini
Jun 1, 1983·European Journal of Pediatrics·G E Janka
Dec 1, 1952·Archives of Disease in Childhood·J W FARQUHAR, A E CLAIREAUX
Oct 16, 2015·BMJ Case Reports·Balaganesh KarmegarajRamesh Samikannu

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