PMID: 11915492Mar 28, 2002Paper

Hemophagocytic syndrome associated with neutropenia after chemotherapy

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
A I BertozziA Robert

Abstract

This retrospective study reports 15 cases of hemophagocytic syndrome in children treated in our department during a eight-year period. Underlying diseases were acute lymphoblastic leukemia (n = 8) acute myeloblastic leukemia (n = 6) and Burkitt lymphoma (n = 1). Hemophagocytic syndrome was suspected after chemotherapy, in case of an unusual prolonged febrile neutropenia (n = 14) or isolated thrombocytopenia (n = 1). That fever was associated with cutaneous, pulmonary, hematologic, digestive and cardiac signs. Biological disorders included hypoprotidemia, hyponatremia, increased liver enzymes and fibrinopenia. Thrombocytopenia was observed in all patients and was associated with neutropenia for 14 of them. Diagnosis of hemophagocytic syndrome was always confirmed by bone marrow aspiration (infiltration with activated macrophages). Infection was documented in eight children. The treatment of hemophagocytic syndrome relied on steroids and resolution of symptoms occurred within three days of therapy. No recurrence of hemophagocytic syndrome was observed with a median follow up of two years and a half. Such complication should be suspected in cases of prolonged febrile neutropenia and/or thrombocytopenia, and confirmed by bone marro...Continue Reading

Citations

Nov 13, 2002·Pharmacoepidemiology and Drug Safety

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