Hemophagocytic Syndrome in Children With Visceral Leishmaniasis

The Pediatric Infectious Disease Journal
Elizabeth F DaherGeraldo B Silva Júnior

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a serious complication of visceral leishmaniasis (VL). The aim of this study is to describe demographical, clinical and laboratory features of HLH in children with VL. This is a retrospective cohort of children with HLH and VL admitted to a tertiary hospital in Northeast, Brazil, from January 2012 to April 2014. Clinical and laboratory data at admission and during hospital stay were reviewed. Acute kidney injury (AKI) was defined according to the pediatric Risk, Injury, Failure, Loss, End-stage kidney disease criteria. A total 127 VL children were admitted, and 35 children had diagnosis of HLH. Mean age was 4.2 ± 4.3 years, with 62.9% males. Mean hospital stay was 29 ± 12 days. Main signs and symptoms were fever (100%), splenomegaly (94.2%) and hepatomegaly (60%). Laboratory findings showed pancytopenia, albumin 3.03 ± 0.77 g/dL, fibrinogen 236.1 ± 117.2 mg/dL, total calcium 8.2 ± 1.2 mEq/L, lactate dehydrogenase 1804 ± 1019 mg/dL, alkaline phosphatase 1275.4 ± 2160.5 IU/L, total bilirubin 1.9 ± 2.4 mg/dL, direct bilirubin 0.67 ± 1.02 mg/dL, indirect bilirubin 1.2 ± 2.2 mg/dL, aspartate aminotransferase 140.0 ± 145.3 IU/L, alanine aminotransferase 71.4 ± 81.1 IU/L, ferritin 4296.5 ± 8...Continue Reading

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Citations

Mar 31, 2016·International Journal of Molecular Sciences·Sofia TorreggianiSusanna Esposito
Sep 2, 2016·Journal of Tropical Pediatrics·Nowneet Kumar BhatSmita Chandra
Feb 25, 2017·BMC Infectious Diseases·Elizabeth De Francesco DaherGeraldo Bezerra da Silva Junior
Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Fernando Henrique Guimarães de CarvalhoSílvio Fernando Guimarães de Carvalho
Feb 13, 2020·Journal of Pediatric Hematology/oncology·Elpis MantadakisAthanassios Chatzimichael
Feb 5, 2021·The Pediatric Infectious Disease Journal·María López MarcosUNKNOWN GAIP (Grupo Andaluz de Infectología e Inmunopatología Pediátrica) Network

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