Hemophilia A and congenital hypofibrinogenemia: a rare association in same family.

Indian Journal of Pediatrics
Biswanath Basu

Abstract

Hemophilia A is the commonest inherited coagulation defect in human beings, whereas congenital hypofibrinogenemia is a much rarer disease. Occurrence of these two inherited diseases in the same family has not been reported so far. Younger sibling of a known case of Hemophilia A presented with recurrent, spontaneously occurring echymotic spots having prolonged PT, APTT, TT and very low absolute fibrinogen level with normal factor VIII level ultimately diagnosed as a case of congenital hypofibrinogenemia.

References

Jan 1, 1983·Seminars in Thrombosis and Hemostasis·E F Mammen
Jan 1, 1995·Klinische Pädiatrie·J V LeenersS Kayser
Aug 1, 1994·American Journal of Hematology·H al-Mondhiry, W C Ehmann

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