Hemophilic arthropathy in a patient with multi-joint replacement: A case report and literature review

Medicine
Wei ZhuXisheng Weng

Abstract

Hemophilic arthropathy (HA) is a crucial morbidity and a major cause of joint pain and disability in patients with hemophilia A. Surgical methods, such as total joint arthroplasty, are of vital importance for end-stage HA treatment, but the feasibility and effects of multi-joint replacement surgery remain debatable. A 24-year-old patient with advanced HA presented multiple joint pain. Physical examination revealed joint tenderness, swelling, and limited activity. Radiographs revealed bilateral knee joints and left elbow joint damage with joint space narrowing, articular facet erosion, and bone deformation. The patient was diagnosed with hemophilic arthropathy with multi-joint lesions. The key points of this case include arthropathy in multiple joints and the management of simultaneous total multi-joint arthroplasty. We performed bilateral total knee arthroplasty and total left elbow arthroplasty simultaneously after adequate preparations. Special attention was paid to factor VIII infusion, hemorrhage control, and other safety precautions perioperatively. After the surgery, no complications, such as infection or aseptic loosening, occurred, and the joints functioned well at follow-up. The surgical outcome and safety of multi-joi...Continue Reading

References

Jan 3, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-Merchan
Jul 22, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-Merchan
Jul 1, 2010·Journal of Thrombosis and Haemostasis : JTH·L A Valentino
Jul 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaUNKNOWN Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia
Sep 21, 2012·Expert Review of Hematology·Mindy L Simpson, Leonard A Valentino
Dec 18, 2013·Seminars in Ultrasound, CT, and MR·Susan CrossNicos Fotiadis
Feb 18, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·A ThèsT Lambert
Sep 12, 2015·Expert Review of Hematology·E Carlos Rodriguez-Merchan
Nov 6, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·S M J MortazaviG Toogeh
Jul 1, 2017·Orthopedics·Christopher R NaccaJohn R Tuttle
Jul 21, 2017·Expert Review of Hematology·E Carlos Rodriguez-Merchan

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Methods Mentioned

BETA
factor replacement therapy
total hip arthroplasty
total elbow arthroplasty

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