PMID: 5939934Aug 5, 1966

Hemopoietic colony-forming units in regenerating mouse liver: suppression by anticoagulants

M L Varon, L J Cole


After hepatic injury induced by carbon tetrachloride, mitotically active hematopoietic cells of nonhepatic origin localize in the liver as judged by an increase in colony-forming nodules in the spleens of lethally irradiated recipient mice on intravenous injection of cells from these livers. The administration of warfarin suppresses the localization of colony-forming units in the regenerating liver by inhibiting the coagulation mechanism of the donor animals.


Related Concepts

Blood Coagulation
Bone Marrow Cells
Toxic Effect of Carbon Tetrachloride
Liver Regeneration
Subcellular Fractions
Vitamin K

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