PMID: 3760593Jan 1, 1986Paper

Hemopoietic effects of intravenous soluble glucan administration

Journal of Immunopharmacology
M L Patchen, T J MacVittie

Abstract

A soluble form of the reticuloendothelial- and immune modulating agent glucan (glucan-F) has been evaluated for its effects on hemopoiesis. A single 5.0 mg intravenous injection of glucan-F into C3H/HeN mice increased peripheral white blood cellularity, bone marrow and splenic cellularity, bone marrow and splenic granulocyte-macrophage progenitor cell numbers (GM-CFC), and splenic pluripotent stem cell (CFU-s) and erythroid progenitor cell (CFU-e) numbers. Serum levels of granulocyte-macrophage colony stimulating activity (CSA) were also elevated following glucan-F administration. These hemopoietic responses correlate well with those previously shown to be induced by intravenous administration of particulate glucan (glucan-P). In contrast to glucan-P, however, intravenous glucan-F administration has been shown not to induce granuloma formation and severe hepatosplenomegaly, thus the potential clinical use of glucan-F as a hemopoietic stimulant is more likely than that of glucan-P.

References

Jan 1, 1976·Journal of Agricultural and Food Chemistry·Y Pomeranz, G S Robbins
Jan 1, 1955·Annual Review of Microbiology·D W TALMAGE

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·M L PatchenJ F Weiss
Jan 1, 1988·International Journal of Immunopharmacology·D L WilliamsN R Di Luzio
Mar 1, 1995·International Journal of Immunopharmacology·M HoferJ Sandula
Feb 1, 1996·International Journal of Immunopharmacology·S F EggerJ E Talmadge
Sep 11, 2002·Archives of Oral Biology·Richard NiedermanPhilip Stashenko
Apr 1, 1995·Zentralblatt für Veterinärmedizin. Reihe A·L KolodzieyskiM Kokardova
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·M L PatchenW E Jackson
Nov 9, 2004·International Immunopharmacology·James TalmadgeKenneth Yates

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