Hemopoietic regeneration in murine spleen following transfusion of normal and irradiated marrow: different response of granulocyte/macrophage and erythroid precursors

Leukemia Research
K H von WangenheimL E Feinendegen

Abstract

To investigate cell proliferation in regenerating spleen, bone marrow of normal and gamma-irradiated donor mice (3 weeks after 5 Gy) was transfused into lethally irradiated recipients. In the donors and in the recipient spleens numbers of CFU-S and progenitor cells were determined. In the irradiated donors the progenitors were at control level after 3 weeks of recovery although CFU-S were still at 50% of control. Recipients of the irradiated marrow received therefore an increased proportion of progenitors. CFU-C appeared to be self-renewing and/or increased in number due to enhanced CFU-S differentiation, but not the erythroid progenitors. CFU-S self-renewal was reduced after 5 Gy. The data suggest that cell differentiation and maturation proceed during early splenic regeneration. The quantity of CFU-C does not necessarily mirror the situation in the stem cell compartment.

References

Jan 1, 1986·Radiation and Environmental Biophysics·K H von WangenheimL E Feinendegen
Jan 1, 1987·Radiation and Environmental Biophysics·K H von WangenheimL E Feinendegen
Jan 4, 2012·Seminars in Cancer Biology·Boris EngelsHans Schreiber

Citations

Feb 1, 1978·The Journal of Clinical Investigation·D G NathanD E Housman
Jan 1, 1986·Radiation and Environmental Biophysics·K H von WangenheimL E Feinendegen
Jan 1, 1985·Annals of the New York Academy of Sciences·K H WangenheimL E Feinendegen
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·A M WuE A McCulloch
Nov 1, 1983·International Journal of Radiation Oncology, Biology, Physics·J H HendryN G Testa
Jan 1, 1980·Leukemia Research·E FrindelF Sainteny
Feb 11, 1982·Nature·M C MagliN Odartchenko
Oct 1, 1962·British Journal of Haematology·C W GURNEYR OLIVER

Related Concepts

Protein S Deficiency
Colony-Forming Units, Hematopoietic
Spleen Colony-forming Unit
Spleen
Murine
Bone Marrow
Biologic Development
Cell Proliferation
Cell Differentiation Process
Cell Division Phases

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