PMID: 11311861Apr 20, 2001Paper

Hemoproteins affect H(2)O(2) removal from rat tissues

The International Journal of Biochemistry & Cell Biology
Paola VendittiS D Meo

Abstract

The capacity of rat liver homogenates and mitochondria to remove H(2)O(2) was determined by comparing their ability to slow fluorescence generated by a H(2)O(2) 'detector' with that of desferrioxamine solutions. H(2)O(2) was produced by glucose oxidase-catalysed glucose oxidation. The capacity to remove H(2)O(2) was expressed as equivalent concentration of desferrioxamine. The method showed changes in the capacity of H(2)O(2) removal after treatment with ter-butylhydroperoxide or glutathione. The H(2)O(2) removal capacity of homogenates and mitochondria from rat liver, heart, and skeletal muscle was compared with their overall antioxidant capacity. For homogenates, the order of both antioxidant and H(2)O(2) removal capacities was liver>heart>muscle. For mitochondria, the order of the antioxidant capacities mirrored that of the homogenates, while the order of the H(2)O(2) removal capacities was heart>muscle>liver. Because H(2)O(2) removal is not only due to H(2)O(2)-metabolizing enzymes, but also to hemoproteins that convert H(2)O(2) into more reactive radicals via Fenton reaction, the higher concentration of cytochromes in mitochondria of cardiac and skeletal muscles can explain the above discrepancy. A higher H(2)O(2) removal ...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Aug 9, 1976·Biochemical and Biophysical Research Communications·P R RichA L Moore
Jul 1, 1990·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
Dec 1, 1987·Journal of Applied Physiology·J K LangR F Burk
Jun 1, 1986·Journal of Applied Physiology·K GohilS E Terblanche
Mar 1, 1974·Analytical Biochemistry·M J Black, R B Brandt
Jul 1, 1968·Analytical Chemistry·G G GuilbaultM Juneau
Jul 15, 1993·European Journal of Biochemistry·H Sies
Dec 1, 1994·Archives of Biochemistry and Biophysics·C D PhungJ F Turrens
Jan 1, 1994·Physiological Reviews·B P Yu
Aug 1, 1995·Archives of Physiology and Biochemistry·P VendittiT De Leo
Aug 15, 1996·Experientia·S Di MeoT De Leo
Mar 1, 1996·The International Journal of Biochemistry & Cell Biology·A LanniF Goglia
May 1, 1995·Archives of Physiology and Biochemistry·S Di MeoT De Leo
Feb 9, 1999·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·P VendittiS Di Meo

❮ Previous
Next ❯

Citations

Aug 2, 2003·Molecular and Cellular Endocrinology·Paola VendittiSergio Di Meo
Aug 19, 2007·Pflügers Archiv : European journal of physiology·Paola VendittiSergio Di Meo
Jul 7, 2011·Journal of Bioenergetics and Biomembranes·P VendittiS Di Meo
Nov 28, 2013·Journal of Bioenergetics and Biomembranes·Paola VendittiSergio Di Meo
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Feb 5, 2013·Mitochondrion·Paola VendittiSergio Di Meo
Nov 22, 2008·Free Radical Biology & Medicine·Paola VendittiSergio Di Meo
Jun 8, 2007·The International Journal of Biochemistry & Cell Biology·P VendittiS Di Meo
Aug 17, 2010·The Journal of Experimental Biology·P VendittiS Di Meo
Feb 20, 2003·Archives of Biochemistry and Biophysics·Paola VendittiSergio Di Meo
Mar 31, 2007·Archives of Biochemistry and Biophysics·P VendittiS Di Meo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Paola VendittiSergio Di Meo
Comparative Biochemistry and Physiology. B, Comparative Biochemistry
H BarréJ L Rouanet
Molecular and Cellular Endocrinology
Paola VendittiSergio Di Meo
© 2021 Meta ULC. All rights reserved