Hemorrhage from cerebral cavernous malformations: The role of associated developmental venous anomalies

Neurology
Bixia ChenPhilipp Dammann

Abstract

To determine the role of associated developmental venous anomalies (DVAs) in intracranial hemorrhage (ICH) caused by cerebral cavernous malformations (CCMs). We analyzed patient registry data of 1,219 patients with cavernous malformations treated in our institution between 2003 and 2018. Patients with spinal and familial CCM and patients without complete MRI data were excluded. The impact of various variables on ICH as a mode of presentation was assessed with multivariate binary logistic regression analysis. Kaplan Meier/Cox regression analysis was performed to analyze cumulative 5-year-risk for (re)hemorrhage and to identify baseline predictors of this outcome. Seven hundred thirty-one patients with CCM were included. Multivariate logistic regression confirmed a statistically significant negative correlation with DVA (odds ratio [OR] 0.635 [95% confidence interval (CI) 0.459-0.878]) and positive correlation with brainstem localization (OR 6.277 [95% CI 4.287-9.191]) with ICH as the mode of presentation. Among 731 patients, 76 experienced (re)hemorrhage during 2,338 person-years of follow-up. Overall cumulative 5-year risk was 24.1% (95% CI 21.1%-27.5%). Cox regression analysis revealed initial presentation with ICH (hazard rat...Continue Reading

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Citations

Jun 10, 2020·Neurology·Alejandro A Rabinstein, Kelly D Flemming
Nov 25, 2020·Neuroradiology·Karolina BrzegowyJerzy A Walocha
Feb 17, 2021·Stroke; a Journal of Cerebral Circulation·Bixia ChenPhilipp Dammann
Oct 29, 2021·Stroke; a Journal of Cerebral Circulation·Alejandro N SantosPhilipp Dammann
Jan 22, 2022·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Alejandro N SantosPhilipp Dammann

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