Hemorrhage induced by intrauterine devices: control by local proteinase inhibition

Fertility and Sterility
P F TauberL J Zaneveld


The intrauterine application of proteinase inhibitors, tranexaminc acid and the pancreatic trypsin inhibitor (Trasylol), reduces or eliminates menorrhagia and intermenstrual bleeding (spotting) produced by an intrauterine device (IUD). A decrease in pain and vaginal (cervical) discharge is also frequently observed. A single application is usually sufficient, more than three never being required. The effect lasts for an average of three cycles. In addition to the clinical use of these agents for the treatment of uterine hemorrhage, the slow release of proteinase inhibitors from an IUD may well be useful in minimizing its side effects without interfering with its contraceptive activity.


Jan 11, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·I SarrisR A Kadir
Jan 1, 1990·Archives of Andrology·D Dinulovic, G Radonjic
Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Guillebaud
Mar 1, 1991·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·M Barthwal, K Srivastava

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Administration, Topical
Cyclohexanecarboxylic Acids
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