Hemorrhagic encephalopathy associated with COVID-19

Journal of Neuroimmunology
Jonathan D KrettMarcus W Koch

Abstract

The mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release syndrome. The patient gradually recovered with supportive care and neurological rehabilitation. Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19.

Citations

Sep 2, 2020·European Journal of Physical and Rehabilitation Medicine·Francesco NegriniUNKNOWN International Multiprofessional Steering Committee of Cochrane Rehabilitation REH-COVER action
Dec 1, 2020·Frontiers in Neurology·Pedro FraimanMarialuisa Zedde
Feb 9, 2021·Reviews in the Neurosciences·Priyanka NaguVineet Mehta
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Islam FayedJeffrey C Mai
Jun 14, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nikolaos Panagiotis MargosJohn Ellul
Aug 27, 2021·The International Journal of Neuroscience·Zeina Hassan OusseiranWafaa Takash Chamoun
Oct 8, 2021·Continuum : Lifelong Learning in Neurology·Michael A Pizzi
Jun 10, 2021·Journal of Medicine and Life·Vitalie VacarasAdrian Mihai Cordos

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