Hemostasis biomarkers in multiple sclerosis

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
N ZiliottoR Zivadinov

Abstract

The aim was to investigate the plasma levels of hemostasis components in multiple sclerosis (MS) and their association with clinical and magnetic resonance imaging (MRI) outcomes. In all, 138 MS patients [85 with relapsing-remitting MS (RR-MS) and 53 with progressive MS (P-MS) with a mean age of 54 years; 72.5% female; median Expanded Disability Status Scale 3.5; mean disease duration 21 years] and 42 age- and sex-matched healthy individuals (HI) were studied. All subjects were examined with 3 T MRI and clinical examinations. Plasma levels of hemostasis factors [procoagulant, factor XII (FXII)] and inhibitors [tissue factor pathway inhibitor (TFPI), thrombomodulin, heparin cofactor II, a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and plasminogen activator inhibitor 1 (PAI-1)] were evaluated by magnetic Luminex assays and enzyme-linked immunosorbent assay. Associations between hemostasis plasma levels and clinical and MRI outcomes were assessed. Lower ADAMTS13 levels were found in MS patients compared to HI (P = 0.008) and in MS patients presenting with cerebral microbleeds compared to those without (P = 0.034). Higher PAI-1 levels were found in MS patients compared to HI (P = 0.02). TFPI...Continue Reading

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Citations

Aug 14, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N ZiliottoF Bernardi
Jun 13, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Zhiyong ShiJun Xu
May 10, 2019·Frontiers in Neurology·Nicole ZiliottoRobert Zivadinov
Aug 23, 2020·International Journal of Molecular Sciences·Angela DziedzicMichal Bijak
Feb 23, 2020·Journal of Neuroinflammation·Kaili LuYuwu Zhao
May 22, 2020·Thrombosis Research·Nicole ZiliottoGiovanna Marchetti
Mar 16, 2021·Matrix Biology Plus·Silvia Redondo-GarcíaJuan Carlos Rodríguez-Manzaneque
Sep 6, 2019·Journal of Vascular Research·Dejan JakimovskiMurali Ramanathan

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