PMID: 2112452Feb 1, 1990Paper

Hemostatic alterations with exercise conditioning in NIDDM

Diabetes Care
W G HornsbyJ A Colwell

Abstract

Various parameters of coagulation and fibrinolysis were measured in 13 men (aged 54 +/- 3 yr) with non-insulin-dependent diabetes mellitus (NIDDM) before and after 12-14 wk of exercise training. Subjects exercised for 30 min 3 times/wk at 70% of maximum O2 consumption (VO2max). Training increased VO2max by 12.5% but did not alter body weight, relative body fat, blood pressure, cholesterol, triglycerides, or high-density lipoprotein cholesterol. Slight downward trends were apparent for fasting glucose and insulin, but glycosylated hemoglobin was unchanged. There were no changes in coagulation parameters of plasminogen, hematocrit, or alpha 2-antiplasmin. Plasma fibrinogen (303 +/- 24.2 vs. 256 +/- 12.3 mg/dl) and fibronectin (380 +/- 41.9 vs. 301 +/- 22.2 micrograms/ml) were significantly reduced (P less than 0.02) by exercise conditioning. Three assays of fibrinolytic activity (tissue plasminogen activator, euglobulin lysis time, and an isotopic measure of fibrinolysis) confirmed that neither basal fibrinolysis nor the fibrinolytic responses to venous occlusion and maximal exercise were significantly altered. Exercise conditioning may have antithrombotic effects in NIDDM by reducing plasma fibrinogen and fibronectin. Although t...Continue Reading

Citations

Dec 1, 2001·Endocrinology and Metabolism Clinics of North America·J A Colwell
Feb 28, 2004·Sports Medicine·Mahmoud S El-SayedSajad Ahmadizad
Mar 31, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·John A Colwell
Feb 3, 2006·Scandinavian Journal of Medicine & Science in Sports·B K Pedersen, B Saltin
Jan 1, 1993·Diabetes Research and Clinical Practice·S C JainB Talukdar
Nov 26, 2015·Scandinavian Journal of Medicine & Science in Sports·B K Pedersen, B Saltin
Jun 1, 2006·Diabetes Research and Clinical Practice·Paul J NielsenSharon A Brown
Feb 25, 2006·Journal of Applied Physiology·Chad M PatonJames M Hagberg
May 5, 2000·Medicine and Science in Sports and Exercise·M S El-SayedM Chester
Jun 1, 1996·Medicine and Science in Sports and Exercise·W L ChandlerM V Vitiello

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