PMID: 15240961Jul 9, 2004Paper

Hemostatic and fibrinolytic activation is less following cutting balloon angioplasty of the coronary arteries

Japanese Heart Journal
Atsushi NamikiTetsu Yamaguchi

Abstract

Recent studies have shown that percutaneous coronary intervention (PCI) activates systemic hemostatic activity, reflecting platelet activation and thrombin formation in the coronary arteries. The present study compared systemic levels of hemostatic markers induced by plain old balloon angioplasty (POBA), coronary stenting (STENT), and cutting balloon (CB) angioplasty. Sixty-one patients with stable angina pectoris, who underwent elective PCI or diagnostic coronary angiography (CAG) alone, were investigated. Patients who underwent PCI were divided into the POBA group (n = 11), the STENT group (n = 27), and the CB group (n = 11). Patients who underwent CAG alone were assigned to the CAG group (n = 12). Blood samples were collected before, 24 hours after, and 3 days after PCI or CAG. Plasma concentrations of prothrombin fragment 1+2 (F1+2), fibrinopeptide A (FPA), thrombin-antithrombin III complex (TAT), and plasminogen activator inhibitor-1 (PAI-1) were measured. In the CB group, the F1+2 (1.23 +/- 0.4 nmol/L) level 3 days after PCI was significantly smaller than that of the POBA group (2.37 +/- 0.5 nmol/L) (P < 0.05). The FPA (1.81 +/- 0.9 ng/mL), TAT (3.36 +/- 1.2 ng/mL) and PAI-1 (23.0 +/- 4.1 ng/mL) levels in the CB group 3 d...Continue Reading

Citations

Apr 13, 2006·European Radiology·Dimitrios TsetisAnna-Maria Belli
May 25, 2012·Cardiovascular Intervention and Therapeutics·Bunji KakuYoshio Hiraiwa
Nov 1, 2007·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Anwar TandarHoward R Lee
Oct 24, 2018·International Angiology : a Journal of the International Union of Angiology·Dimitrios M KapetaniosKonstantinos O Papazoglou

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