Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Kenji FukushimaRené Tolba

Abstract

Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (n = 10), fibrin glue (n = 10), and saline groups (n = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area. Bleeding time until hemostasis and blood loss were recorded. After 7 days, body weight, hematology parameters, and serum levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase were measured. Simultaneously, the severity of intra-abdominal adhesion was evaluated. The mean bleeding time in the MAR (38 ± 10 s) and fibrin glue groups (65 ± 17 s) was significantly shorter than that in the saline group (186 ± 12 s). Similarly, the mean blood loss in the MAR (9 ± 3 g) and fibrin glue groups (9 ± 3 g) was significantly less than that in the saline group (23 ± 4 g). No significant differences in bleeding time and blood loss were found between the MAR and fibrin glue ...Continue Reading

References

Oct 1, 1990·Archives of Surgery·C de VirgilioJ M Robertson
Oct 1, 1996·World Journal of Surgery·S UranüsJ Kraft-Kirz
May 7, 2003·World Journal of Surgery·Jing-mou GaoXi Lin
Jun 26, 2004·Journal of the American College of Surgeons·Justin B DimickLisa M Colletti
Jun 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Monika KroezGerhard Dickneite
Sep 19, 2006·Acta Cirúrgica Brasileira·Sthela Maria Murad-RegadasPaulo Roberto Leitão de Vasconcelos
Jun 26, 2007·Journal of Materials Science. Materials in Medicine·P FerreiraM H Gil
Jul 28, 2007·Digestive Surgery·Marieke T de BoerRobert J Porte
Jan 8, 2008·World Journal of Gastroenterology : WJG·Arif Hakan DemirelMustafa Kisakurek
Sep 12, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ryan J McCollElijah Dixon
Feb 3, 2009·The Journal of Surgical Research·Nathan E HoffmannMark H Ereth
Jun 9, 2009·The Kaohsiung Journal of Medical Sciences·Huseyin Ayhan KayaogluNurper Onuk Filiz
Sep 1, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Elizabeth A BoonstraMarieke T de Boer
Dec 17, 2009·Annals of Surgery·Hardean E AchneckJeffrey H Lawson
Dec 1, 2010·Deutsches Ärzteblatt International·Dörthe BrüggmannAndreas Hackethal
Nov 2, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Masci EmiliaLongoni Mauro
Mar 24, 2012·Digestive Surgery·Marieke T de BoerRobert J Porte
Apr 23, 2013·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint
Oct 11, 2013·Digestive Surgery·R LochanS A White

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Citations

Nov 23, 2020·Journal of Biomedical Informatics·Stefan BruchRené H Tolba
Jun 19, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Marius HeitzerAli Modabber
Jun 19, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yifan ZhaoXiaobing Fu

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