Hemostatic markers before operation in patients with acutely symptomatic nonruptured and ruptured infrarenal abdominal aortic aneurysm

Journal of Vascular Surgery
D J AdamA W Bradbury

Abstract

In patients with acutely symptomatic but nonruptured abdominal aortic aneurysm (AAA), emergent repair is associated with an increased mortality rate as compared with semi-elective repair. Previous results have shown that ruptured but not asymptomatic AAA repair is associated with intense thrombin generation and inhibition of systemic fibrinolysis. The purpose of this study was to determine whether circulating markers of coagulation and fibrinolysis may be used to distinguish acutely symptomatic nonruptured and ruptured AAA. A prospective study was performed of 44 patients who underwent emergency AAA repair for suspected rupture. Platelet count, fibrinogen level, prothrombin time, activated partial thromboplastin time, tissue plasminogen activator (t-PA) activity, plasminogen activator inhibitor (PAI) activity, prothrombin fragment (PF) 1+2 level, and D dimer level were measured before surgery. When compared with ruptured AAAs (n = 37), acutely symptomatic nonruptured AAAs (n = 7) were associated with increased fibrinogen level (P =.033), reduced activated partial thromboplastin time (P =.043), increased t-PA activity (P =.023), reduced PAI activity (P =.005), reduced PF 1+2 level (P =.001), and reduced D dimer level (P =.005; a...Continue Reading

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Citations

Jun 23, 2009·Annals of Biomedical Engineering·Zhipeng LiuGhassan S Kassab
Sep 3, 2013·Progress in Cardiovascular Diseases·Guido H W van BogerijenSanti Trimarchi
Oct 26, 2010·The Annals of Thoracic Surgery·Santi TrimarchiJohn A Elefteriades
Oct 28, 2009·The American Journal of Emergency Medicine·Yu-Hui ChiuChun-I Huang
Nov 30, 2005·European Journal of Internal Medicine·A Fernandez-Bustamante, A Jimeno
Oct 9, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E SkagiusA Henriksson
Nov 10, 2004·Annals of Vascular Surgery·D J AdamA W Bradbury
Jun 1, 2005·Thrombosis Research·Hüseyin AltinyollarUğur Berberoğlu
Oct 28, 2006·Angiology·Hamad S Al-BarjasJulian A Scott
Mar 11, 2005·Abdominal Imaging·P CastelliA Bacuzzi
Feb 19, 2013·Surgery Today·Masahiro MatsushitaAkihito Idetsu
Oct 15, 2019·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Giuseppe SangiorgiEugenio Martelli

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