PMID: 3759248Jan 1, 1986Paper

Hemostatic parameters influenced by imipenem/cilastatin

Infection
M ZiemenH K Breddin

Abstract

Seven patients were treated for bacterial infections with imipenem/cilastatin. Imipenem is a new broad-spectrum beta-lactam antibiotic with antimicrobial activity against gram-positive and gram-negative bacilli. Before and during treatment parameters of blood coagulation and platelet function were studied. Blood coagulation was not influenced by the antibiotic. But there was a temporary inhibition of collagen-induced platelet aggregation during the first days of treatment. No clinical signs of enhanced spontaneous bleeding tendency were observed.

References

Nov 13, 1976·Lancet·K AndrassyH Storch
Nov 1, 1979·The American Journal of the Medical Sciences·E A NatelsonM W Bradshaw
Jan 1, 1977·British Journal of Haematology· Cazenave J-PJ F Mustard
Jul 1, 1985·Reviews of Infectious Diseases·P M Shah
Aug 8, 1974·The New England Journal of Medicine·C H BrownC P Alfrey

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Citations

Apr 4, 2006·American Journal of Veterinary Research·Jinelle A WebbPatricia A Gentry

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