Hemostatic resuscitation for massive bleeding: the paradigm of plasma and platelets--a review of the current literature

Transfusion
Pär I Johansson, J Stensballe

Abstract

Continued hemorrhage remains a major contributor of mortality in massively transfused patients and controversy regarding the optimal management exists. Recent studies indicate a possible survival benefit in patients receiving a higher ratio of plasma and platelets (PLTs) to red blood cells (RBCs) than what is recommended in current transfusion guidelines. English databases were searched for reports of patients receiving massive transfusion that tested the effects of administration of plasma and/or PLTs in relation to RBCs on survival from January 1990 to March 2009. Fourteen retrospective studies involving 4594 patients were identified. Six tested the effect on survival in relation to fresh-frozen plasma (FFP)-to-RBC ratio, and five investigated FFP- and PLT-to-RBC ratios. Two studies evaluated implementation of massive transfusion protocols with preemptive FFP and PLT administration; one study based transfusion therapy on the result of the thrombelastograph (TEG) analysis versus historic controls. All studies reviewed demonstrate a survival benefit for patients who receive more FFP and PLT as part of the hemostatic resuscitation. When TEG was used to guide transfusion therapy an increase in FFP and PLT was also seen when compa...Continue Reading

References

Mar 1, 1995·Journal of Vascular Surgery·A W BradburyJ L Duncan
May 20, 1999·Chest·F StéphanA Flahault
Aug 16, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·N Salooja, D J Perry
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenneth G MannKathleen Brummel
Sep 27, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D J AdamA W Bradbury
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jean-François HardyUNKNOWN Groupe d'intérêt en Hémostase Périopératoire
Aug 17, 2005·Vox Sanguinis·P I JohanssonH Sørensen
Oct 14, 2005·Critical Care : the Official Journal of the Critical Care Forum·John R Hess, Seppo Hiippala
May 5, 2006·Seminars in Thrombosis and Hemostasis·Harold R RobertsDougald M Monroe
Jul 1, 2006·Anesthesiology·UNKNOWN American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies
Aug 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Marcel Levi, Steven M Opal
Aug 4, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Ian J WelsbyTong J Gan
Nov 17, 2006·British Journal of Haematology·UNKNOWN British Committee for Standards in HaematologyP J Hamilton
Jan 12, 2007·The Journal of Trauma·Ernest A GonzalezBruce A McKinley
May 13, 2008·The Journal of Trauma·Karim BrohiJean-François Pittet
Jul 18, 2008·Critical Care Medicine·Jeremy G PerkinsCharles E Bolan
Oct 14, 2008·The Journal of Trauma·John R HessBertil Bouillon
Feb 11, 2009·The Journal of Trauma·Christopher W SnyderJeffrey D Kerby
Mar 12, 2009·The Journal of Trauma·Pedro G R TeixeiraPeter Rhee
Jun 16, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Roger C CarrollStanley J Kurek

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Citations

Oct 12, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·O HenselerR Seitz
Aug 13, 2013·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Theodoros I Tosounidis, Peter V Giannoudis
Feb 25, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Megan A Hayter
Jul 16, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Olaf HenselerRainer Seitz
Nov 26, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·David J Dries
Dec 9, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Jesper DirksPär I Johansson
Apr 13, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Anders R NakstadHans E Heier
Mar 12, 2011·Critical Care : the Official Journal of the Critical Care Forum·Nicola CurrySimon Stanworth
Aug 30, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Romi Sinha, David Roxby
Jan 13, 2015·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Arne DriessenMarc Maegele
Dec 12, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·J KaczynskiJ Hilton
Feb 11, 2012·Medicina intensiva·E Fernández-HinojosaS R Leal-Noval
May 1, 2012·Air Medical Journal·Luke D Lawton
Jul 13, 2011·Journal of Intensive Care Medicine·Gordon M Riha, Martin A Schreiber
Nov 25, 2017·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Matthias FröhlichUNKNOWN TraumaRegister DGU
Feb 5, 2016·The British Journal of Surgery·S J StanworthK Brohi
Jun 12, 2018·Bone Marrow Research·Anupama PatilChhagan Bihari
May 22, 2010·Internal and Emergency Medicine·Marco MariettaGiuseppe Torelli
Apr 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Giuseppe NardiGiulia Ranaldi
Apr 22, 2011·The British Journal of Surgery·K ThorsenK Søreide
Sep 15, 2012·The Journal of Trauma and Acute Care Surgery·Lisa M Baumann KreuzigerDavid J Dries
Oct 19, 2012·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Megan A HayterJames Baker
Jan 5, 2014·British Journal of Haematology·Shubha AllardBeverley J Hunt
Jan 8, 2014·Journal of Veterinary Emergency and Critical Care·Lee Palmer, Linda Martin
Feb 12, 2014·Current Opinion in Anaesthesiology·Jakob StensballePär I Johansson
Jul 26, 2014·Acta Anaesthesiologica Scandinavica·J LundeA Afshari
Dec 3, 2014·Anaesthesia·A Cap, B J Hunt
Feb 5, 2015·Angewandte Chemie·Damien KudelaGalen D Stucky
Jan 18, 2011·Hematology·Thomas G DeLoughery
Jul 1, 2014·Current Opinion in Critical Care·Marcie FeinmanElliott R Haut
Feb 21, 2014·The Journal of Trauma and Acute Care Surgery·Anna Sina P MeyerPär I Johansson
Mar 19, 2015·Shock·Natasha van ZylJohn F Fraser
Jan 18, 2013·Transfusion·Jostein S Hagemo
Feb 7, 2013·Current Opinion in Anaesthesiology·John B Holcomb, Sam Gumbert
Apr 9, 2016·Langenbeck's Archives of Surgery·Andreas S PetersDittmar Böckler
Aug 1, 2018·Obstetrical & Gynecological Survey·Daneil L Jackson, Thomas G DeLoughery
Jun 26, 2013·Asian Pacific Journal of Tropical Medicine·Yun-Fu LuShun-Wu Chang
Oct 24, 2014·Current Opinion in Critical Care·Andrew Cap, Beverley Hunt

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