Hemostatic variables in homozygous familial hypercholesterolemia. Effect of regular plasma cholesterol removal by low density lipoprotein apheresis

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
G Di MinnoG Gallotta

Abstract

Plasma levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and the in vitro ability of platelets to aggregate and of monocytes to express procoagulant (tissue factor) activity (PCA) were evaluated in five patients who are homozygous for familial hypercholesterolemia (FH) before and after a single and a regular 5-month cholesterol removal by low density lipoprotein (LDL) apheresis. The biweekly procedure resulted in a 25% to 30% reduction (approximately 150 mg/dl) in total and LDL cholesterol (both were greater than 550 mg/dl at the beginning of the study). The basal levels of t-PA antigen and fibrinolytic activity before and after 10 minutes of venous stasis, basal PAI activity, and PAI-1 antigen were comparable to controls and were not affected by LDL apheresis. Likewise, regardless of the cholesterol removal, the PCA of freshly isolated monocytes and that of monocytes incubated with lipopolysaccharide did not differ from control values. Finally, the pre-apheresis sensitivity of platelets to adenosine diphosphate, arachidonic acid, and collagen was 1.5 to 2 times the normal value. This ratio was unchanged throughout the 5-month procedure. We conclude that fibrinolysis and monocyte PCA are no...Continue Reading

References

Jun 17, 1976·The New England Journal of Medicine·M S Brown, J L Goldstein
Feb 1, 1979·Teratology·H C Srivastava, P P Rao
Nov 2, 1976·Biochemistry·S J Shattil, R A Cooper
Mar 1, 1975·The Journal of Clinical Investigation·S J ShattilR A Cooper
Jan 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G Di Minno, M Mancini
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·I Juhan-VagueD Collen
Feb 20, 1986·The New England Journal of Medicine·R Ross
Jun 11, 1987·The New England Journal of Medicine·J Hirsh
Aug 31, 1985·British Medical Journal·J A ParamoF van de Werf
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G DiMinnoM Mancini
Feb 8, 1985·Biochimica Et Biophysica Acta·B P Schick, P K Schick
Feb 21, 1974·The New England Journal of Medicine·A C CarvalhoR S Lees
Jun 6, 1981·Lancet·G R Thompson
Jun 1, 1983·The Journal of Clinical Investigation·M ColucciN Semeraro
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S YokoyamaA Yamamoto
Jan 3, 1980·The New England Journal of Medicine·M J StuartJ G White
Jun 1, 1980·British Heart Journal·G R ThompsonR E Steiner

❮ Previous
Next ❯

Citations

Jul 31, 2008·Journal of Thrombosis and Thrombolysis·Vincent M G MaherFelicita Andreotti
Jun 4, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·K G BurnandA Smith
Jul 1, 1994·European Journal of Clinical Investigation·A BröijersénP Hjemdahl
Jun 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E StragliottoE Tremoli
Nov 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M MargaglioneM Mancini
Mar 22, 2012·Medicinal Research Reviews·Valérie CapraG Enrico Rovati
Sep 1, 1992·Current Problems in Cardiology·J S Prihoda, D R Illingworth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.