Hemostatic wound dressings: Predicting their effects by in vitro tests

Journal of Biomaterials Applications
Cornelia WiegandSandra Stoppelkamp

Abstract

Application of controlled in vitro techniques can be used as a screening tool for the development of new hemostatic agents allowing quantitative assessment of overall hemostatic potential. Several tests were selected to evaluate the efficacy of cotton gauze, collagen, and oxidized regenerated cellulose for enhancing blood clotting, coagulation, and platelet activation. Visual inspection of dressings after blood contact proved the formation of blood clots. Scanning electron microscopy demonstrated the adsorption of blood cells and plasma proteins. Significantly enhanced blood clot formation was observed for collagen together with β-thromboglobulin increase and platelet count reduction. Oxidized regenerated cellulose demonstrated slower clotting rates not yielding any thrombin generation; yet, led to significantly increased thrombin-anti-thrombin-III complex levels compared to the other dressings. As hemostyptica ought to function without triggering any adverse events, induction of hemolysis, instigation of inflammatory reactions, and initiation of the innate complement system were also tested. Here, cotton gauze provoked high PMN elastase and elevated SC5b-9 concentrations. A range of tests for desired and undesired effects of m...Continue Reading

References

Sep 14, 1990·Biochimica Et Biophysica Acta·Y Kawamoto, M Kaibara
Feb 1, 1988·Journal of Biomedical Materials Research·R EloyJ Belleville
Feb 1, 1983·American Journal of Surgery·D ColnL M Buja
Jan 1, 1983·Biomaterials, Medical Devices, and Artificial Organs·P N SawyerB Stanczewski
Aug 1, 1980·The Journal of Trauma·M E SilversteinM Chvapil
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·C P PathakJ A Hubbell
Dec 1, 1996·The Journal of Surgical Research·W R WagnerP C Johnson
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·B A Bouchard, P B Tracy
Jun 29, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Claudio SchonauerAldo Moraci
Sep 9, 2004·Seminars in Thrombosis and Hemostasis·Peter N Walsh
Oct 20, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yasuko Tomizawa
Mar 15, 2006·The Journal of Trauma·Anthony E PusateriKathy L Ryan
Nov 6, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jolyon JestyJack Niemiec
Mar 9, 2010·Journal of Medical Case Reports·Preston B RichBruce A Cairns
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S C NairA Srivastava
Mar 23, 2011·Journal of Materials Science. Materials in Medicine·Ferdinand I BroekemaRudolf R M Bos
Aug 3, 2014·Journal of Biomaterials Applications·Kevin M LewisHeinz Gulle
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Zhen ZhenYufeng Zheng
Feb 11, 2015·Journal of Materials Science. Materials in Medicine·Stefanie KrajewskiHans P Wendel
Dec 2, 2015·Journal of Translational Medicine·Julian-Dario RembeEwa K Stuermer
Jan 15, 2016·The Thoracic and Cardiovascular Surgeon·Stefanie KrajewskiHans Peter Wendel

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Citations

Aug 25, 2021·European Journal of Dentistry·Maria Vitoria Oliveira DantasLuanna Abílio Diniz Melquiades de Medeiros

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Methods Mentioned

BETA
scanning electron microscopy
ELISA
Assay

Software Mentioned

Excel

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