PMID: 8603931Nov 1, 1995Paper

Hemotoxic effects of a dermally applied coal coprocessing product in the rat

Journal of Applied Toxicology : JAT
A P YagminasV E Valli

Abstract

The present study was conducted as part of a larger project to determine the toxicity of dermally applied coal coprocessing products. Groups of male and female rats were administered, dermally, heavy gas oil II (HGOII) at 8.7, 20.8, 50.0 and 120 mg kg(-1) body wt, day(-1) for 91 days. A coal liquefaction product was given as positive control at 120 mg kg(-1) body wt. day(-1). Saline was used on control animals. At termination, the blood and bone marrow were taken from the animals and subjected to hematological examination. Dose-dependent hematological effects were seen in peripheral blood in HGOII-treated animals and consisted of significantly reduced hemoglobin, hematocrit, red cell count and platelet count. Mean corpuscular volume was increased, along with mean corpuscular hemoglobin, at the highest dose level. Red cell protoporphyrin, total iron and total iron binding capacity were also significantly elevated at this dose level. Morphological analysis of blood showed increases in polychromatic red cells, schizocytes, Howell-Jolly bodies, injured cells, hypersegmented neutrophils and shift platelets primarily at the highest dose level. In addition, there was notable anisocytosis, microcytosis and macrocytosis. Quantitative bo...Continue Reading

References

Aug 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·I ChuV E Valli
Jul 1, 1991·Journal of Toxicology and Environmental Health·I ChuV E Valli
Jan 1, 1988·Journal of Toxicology and Environmental Health·I ChuV E Valli
Jan 1, 1988·Journal of Toxicology and Environmental Health·I ChuR Otson
Mar 1, 1988·Bulletin of Environmental Contamination and Toxicology·A YagminasD C Villeneuve
Aug 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D L SpringerD D Mahlum

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