Hemozoin in Malarial Complications: More Questions Than Answers.

Trends in Parasitology
Thao-Thy PhamPhilippe E Van den Steen

Abstract

Plasmodium parasites contain various virulence factors that modulate the host immune response. Malarial pigment, or hemozoin (Hz), is an undegradable crystalline product of the hemoglobin degradation pathway in the parasite and possesses immunomodulatory properties. An association has been found between Hz accumulation and severe malaria, suggesting that the effects of Hz on the host immune response may contribute to the development of malarial complications. Although the immunomodulatory roles of Hz have been widely investigated, many conflicting data exist, likely due to the variability between experimental set-ups and technical limitations of Hz generation and isolation methods. Here, we critically assess the potential immunomodulatory effects of Hz, its role in malarial complications, and its potential effects after parasite clearance.

References

Mar 1, 1967·Annals of Tropical Medicine and Parasitology·T SrichaikulP Jeumtrakul
Dec 20, 1996·Molecular and Biochemical Parasitology·M D GreenA A Lal
Jan 29, 2003·The Journal of Infectious Diseases·Georges E GrauMalcolm E Molyneux
Nov 19, 2003·Biochemical and Biophysical Research Communications·Douglas J PerkinsAltaf A Lal
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maritza JaramilloMartin Olivier
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oleksii A SkorokhodEvelin Schwarzer
Jul 27, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Clare K CarneyDavid W Wright
Jan 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peggy ParrocheDouglas T Golenbock
Nov 6, 2007·Trends in Parasitology·D Channe Gowda
Dec 18, 2007·Molecular and Biochemical Parasitology·Timothy J Egan
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason W GriffithRichard Bucala
Dec 31, 2009·PloS One·Abigail A LamikanraDavid J Roberts
Feb 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juliette DiouMichel J Tremblay
Mar 6, 2010·Journal of Biomedicine & Biotechnology·Nicoletta BasilicoDonatella Taramelli
Jun 15, 2010·Microbes and Infection·Michael HawkesKevin C Kain
Mar 15, 2011·Human Pathology·Richard WhittenTerrie E Taylor
Oct 27, 2011·PloS One·Fikregabrail Aberra KassaMartin Olivier
Jan 21, 2012·The American Journal of Pathology·Mark R GillrieMay Ho
May 9, 2012·Malaria Research and Treatment·Rosangela FritaThomas Hänscheid
Jan 19, 2013·American Journal of Respiratory Cell and Molecular Biology·Katrien DeroostPhilippe E Van den Steen
Jun 8, 2013·Trends in Parasitology·Philippe E Van den SteenGhislain Opdenakker

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Peggy ParrocheDouglas T Golenbock
Indian Medical Gazette
J H Tull Walsh
Microbes and Infection
Marina Tiemi ShioMartin Olivier
© 2021 Meta ULC. All rights reserved