Hemozoin is a product of heme detoxification in the gut of the most medically important species of the family Opisthorchiidae

International Journal for Parasitology
Maria LvovaViatcheslav Mordvinov

Abstract

Many species of trematodes such as Schistosoma spp., Fasciola hepatica and Echinostoma trivolvis are blood-feeding parasites. Nevertheless, there is no consensus on the feeding habits of the family Opisthorchiidae (Opisthorchis felineus, Opisthorchis viverrini and Clonorchis sinensis). Previously, histological studies of O. felineus and C. sinensis revealed some dark stained material in their gut lumen. In this study we conducted a comprehensive analysis of the gut contents of three members of the family Opisthorchiidae (O. felineus, O. viverrini and C. sinensis). Using transmission electron microscopy, we demonstrated for the first known time the presence of disintegrating blood cells in the gut of O. felineus as well as electron-dense crystals in the gut of O. felineus and C. sinensis. Electron energy loss spectroscopy revealed iron atoms in these crystals, and mass spectrometry of the purified pigment demonstrated the presence of heme. Fourier-transform infrared spectroscopy identified the signature peaks of the common iron-carboxylate bond characteristic in crystals isolated from O. felineus and C. sinensis. Scanning electron microscopy showed layered ovoid crystals of various sizes from 50 nm to 2 μm. Morphological, chemic...Continue Reading

References

Apr 5, 2000·Nature·S PagolaS K Madsen
Nov 23, 2000·Molecular and Biochemical Parasitology·M F OliveiraS T Ferreira
Mar 20, 2001·Molecular and Biochemical Parasitology·M M ChenD J Sullivan
Jul 20, 2002·Blood·Viktória JeneyGyörgy Balla
Jul 26, 2002·Analytical Chemistry·P A DemirevN Kumar
Sep 28, 2002·Acta Crystallographica. Section D, Biological Crystallography·D Scott BohlePeter W Stephens
Aug 30, 2003·Molecular and Biochemical Parasitology·Gregory S NolandDavid J Sullivan
Jul 1, 1955·The Journal of Pathology and Bacteriology·P C HOU
Nov 13, 2003·Acta Tropica·Banchob Sripa
Jan 25, 2005·Emerging Infectious Diseases·Orit YossepowitchMichael Dan
May 27, 2005·Toxicology Letters·Sanjay Kumar, Uday Bandyopadhyay
Jun 22, 2005·Trends in Parasitology·Jennifer F FriedmanStephen T McGarvey
Jul 16, 2005·International Journal for Parasitology·John M PisciottaDavid Sullivan
Mar 21, 2006·International Journal for Parasitology·Jaap J Van HellemondAloysius G M Tielens
Jul 15, 2009·Clinical Microbiology Reviews·Jennifer Keiser, Jürg Utzinger
Nov 20, 2010·Parasites & Vectors·Shu Qin TohMalcolm K Jones
Jul 12, 2011·Parasitology International·Sung-Tae Hong, Yueyi Fang
Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Monika ChughPawan Malhotra
Aug 14, 2013·Trends in Parasitology·Márcia BouraThomas Hänscheid
Mar 19, 2014·Science & Justice : Journal of the Forensic Science Society·R BradshawS Francese

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Citations

Nov 22, 2019·Frontiers in Veterinary Science·Irina V SaltykovaPaul J Brindley
Jun 8, 2018·Frontiers in Immunology·Adriana Lima VallochiPatricia T Bozza
Apr 4, 2021·Pathogens·Adam P S Bennett, Mark W Robinson

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